PRODUCT NAME: Nitroso Derivative Impurity of Desmethyl Ponatinib
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	NIO-451
Lot Number	Sample COA
Batch Quantity	Sample COA
CAS Number	NA
Mol. Formula	C28H24F3N7O2
Molecular Wt	547.5
Long Term Storage Condition	Keep container tightly closed in a dry and well-ventilated place	Handling instruction	Sample COA
Chemical Name	Nitroso Derivative Impurity of Desmethyl Ponatinib
Synonyms	3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-nitrosopiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Test	Results
Appearance
Identification by 1H NMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Purity	NLT 98%
Wt. Loss by TGA	Sample COA
% Potency	Sample COA
Solubility
QC Release Date	Sample COA
Attachments	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption