PRODUCT NAME: Cobimetinib Nitroso Impurity 1
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	NIO-662
Item/Batch Number	Sample COA
Quantity	Sample COA
CAS Number	NA
Mol. Formula	C21H20F3IN4O3
Molecular Wt	560.3
Synonyms	(S)-N-(2,3-Difluoro-6-(3-hydroxy-3-(piperidin-2-yl)azetidine-1-carbonyl)phenyl)-N-(2-fluoro-4-iodophenyl)nitrous amide
Long Term Storage Condition	Keep container tightly closed in a dry and well-ventilated place
Handling instruction	Sample COA

Test	Results
Appearance
Water content by KF/TGA	Sample COA
% Potency = [100 - (Water content by KF)] X HPLC Purity)] / 100	Sample COA
Identification by HNMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Solubility
Purity	NLT 98%
Analysis Date (Release Date)	Sample COA
Attachments	Sample COA
Other Information	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption