PRODUCT NAME: Acalabrutinib Impurity 18
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	ATB-032
Lot Number	Sample COA
Batch Quantity	Sample COA
CAS Number	1148-11-4
Mol. Formula	C13H15NO4
Molecular Wt	249.32 g/mol
Long Term Storage Condition	Room temperature (20–25°C) in a dry place	Handling instruction	Sample COA
IUPAC	((Benzyloxy)carbonyl)-L-proline
Chemical Name	Acalabrutinib Impurity 18
Synonyms	(2S)-1,2-Pyrrolidinedicarboxylic Acid 1-(Phenylmethyl) Ester; (S)-1,2-Pyrrolidinedicarboxylic Acid 1-(Phenylmethyl) Ester; (2S)-1,2-L-2-Pyrrolidinedicarboxylic Acid 1-Benzyl Ester; (2S)-1-Pyrrolidinedicarboxylic Acid 1-(Phenylmethyl) Ester; (2S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic Acid

Test	Results
Appearance	White to off-white crystalline powder
Identification by 1H NMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Purity	NLT 98%
Wt. Loss by TGA	Sample COA
% Potency	Sample COA
Solubility
QC Release Date	Sample COA
Attachments	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption