PRODUCT NAME: Afatinib Impurity E
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	AFI-054
Item/Batch Number	Sample COA
Quantity	Sample COA
CAS Number	2223677-63-0
Mol. Formula	C24H25Cl2N5O3
Molecular Wt	502.4 g/mol
IUPAC	(S,E)-N-(4-((3,4-dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Synonyms	4-(Dimethylamino)but-2-enamide, (S,E)-N-(4-((3,4-dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-; Afatinib Dichloro Analog
Long Term Storage Condition	2-8°C Refrigerator
Handling instruction	Sample COA

Test	Results
Appearance	solid powder
Water content by KF/TGA	Sample COA
% Potency = [100 - (Water content by KF)] X HPLC Purity)] / 100	Sample COA
Identification by HNMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Solubility
Purity	NLT 98%
Analysis Date (Release Date)	Sample COA
Attachments	Sample COA
Other Information	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption