PRODUCT NAME: Cobimetinib Nitroso Impurity 2
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	NIO-661
Lot Number	Sample COA
Batch Quantity	Sample COA
CAS Number	NA
Mol. Formula	C21H19F3IN5O4
Molecular Wt	589.3
Long Term Storage Condition	Keep container tightly closed in a dry and well-ventilated place	Handling instruction	Sample COA
Chemical Name	Cobimetinib Nitroso Impurity 2
Synonyms	(S)-N-(2,3-Difluoro-6-(3-hydroxy-3-(1-nitrosopiperidin-2-yl)azetidine-1-carbonyl)phenyl)-N-(2-fluoro-4-iodophenyl)nitrous amide

Test	Results
Appearance
Identification by 1H NMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Purity	NLT 98%
Wt. Loss by TGA	Sample COA
% Potency	Sample COA
Solubility
QC Release Date	Sample COA
Attachments	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption