PRODUCT NAME: Afatinib Impurity B
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	AFI-013
Item/Batch Number	Sample COA
Quantity	Sample COA
CAS Number	314771-76-1
Mol. Formula	C18H16ClFN4O2
Molecular Wt	374.8 g/mol
IUPAC	N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine
Synonyms	Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol); N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine; Des(4-dimethylamino-2-en-1-oxo)butyl Afatinib
Long Term Storage Condition	2-8°C Refrigerator
Handling instruction	Sample COA

Test	Results
Appearance	Dark Yellow Solid
Water content by KF/TGA	Sample COA
% Potency = [100 - (Water content by KF)] X HPLC Purity)] / 100	Sample COA
Identification by HNMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Solubility
Purity	NLT 98%
Analysis Date (Release Date)	Sample COA
Attachments	Sample COA
Other Information	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption