PRODUCT NAME: Acalabrutinib Impurity 2
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	ATB-034
Item/Batch Number	Sample COA
Quantity	Sample COA
CAS Number	NA
Mol. Formula	C21H19N5O3
Molecular Wt	389.4 g/mol
IUPAC	(4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]benzoic acid)
Synonyms	(S)-4-(8-Amino-3-(1-but-2-ynoylpyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)benzoic acid; PROTAC linker acid intermediate VHL-ACID-02
Long Term Storage Condition	2-8°C Refrigerator
Handling instruction	Sample COA

Test	Results
Appearance	Light yellow to beige crystalline powder
Water content by KF/TGA	Sample COA
% Potency = [100 - (Water content by KF)] X HPLC Purity)] / 100	Sample COA
Identification by HNMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Solubility
Purity	NLT 98%
Analysis Date (Release Date)	Sample COA
Attachments	Sample COA
Other Information	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption