PRODUCT NAME: Acalabrutinib Impurity 12
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	ATB-027
Lot Number	Sample COA
Batch Quantity	Sample COA
CAS Number	NA
Mol. Formula	C26H23N7O3
Molecular Wt	481.5 g/mol
Long Term Storage Condition	2-8°C under nitrogen	Handling instruction	Sample COA
IUPAC	(S)-8-Amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazine 7-oxide
Chemical Name	Acalabrutinib Impurity 12
Synonyms	(S)-1-[4-(Pyridin-2-ylcarbamoyl)phenyl]-3-[1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-8-amine 7-oxide; N-Oxide derivative of PROTAC linker intermediate

Test	Results
Appearance	Pale yellow crystalline solid
Identification by 1H NMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Purity	NLT 98%
Wt. Loss by TGA	Sample COA
% Potency	Sample COA
Solubility
QC Release Date	Sample COA
Attachments	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption