PRODUCT NAME: Acalabrutinib Impurity 12
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	ATB-027
Item/Batch Number	Sample COA
Quantity	Sample COA
CAS Number	NA
Mol. Formula	C26H23N7O3
Molecular Wt	481.5 g/mol
IUPAC	(S)-8-Amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazine 7-oxide
Synonyms	(S)-1-[4-(Pyridin-2-ylcarbamoyl)phenyl]-3-[1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-8-amine 7-oxide; N-Oxide derivative of PROTAC linker intermediate
Long Term Storage Condition	2-8°C under nitrogen
Handling instruction	Sample COA

Test	Results
Appearance	Pale yellow crystalline solid
Water content by KF/TGA	Sample COA
% Potency = [100 - (Water content by KF)] X HPLC Purity)] / 100	Sample COA
Identification by HNMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Solubility
Purity	NLT 98%
Analysis Date (Release Date)	Sample COA
Attachments	Sample COA
Other Information	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption