PRODUCT NAME: N-Nitroso Lorlatinib impurity-4
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	NIO-336
Lot Number	Sample COA
Batch Quantity	Sample COA
CAS Number	NA
Mol. Formula	C21H20FN7O4
Molecular Wt	453.4
Long Term Storage Condition	Keep container tightly closed in a dry and well-ventilated place	Handling instruction	Sample COA
Chemical Name	N-Nitroso Lorlatinib impurity-4
Synonyms	(R)-2-(1-((2-Amino-5-(5-cyano-1-methyl-3-((methyl(nitroso)amino)methyl)-1H-pyrazol-4-yl)pyridin-3-yl)oxy)ethyl)-4-fluorobenzoic acid

Test	Results
Appearance
Identification by 1H NMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Purity	NLT 98%
Wt. Loss by TGA	Sample COA
% Potency	Sample COA
Solubility
QC Release Date	Sample COA
Attachments	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption