PRODUCT NAME: Impurity 2 of Ibrutinib
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	IBR-002
Item/Batch Number	Sample COA
Quantity	Sample COA
CAS Number	2031255-27-1
Mol. Formula	C₂₈H₂₆N₆O₃
Molecular Wt	494.54
Synonyms	1-[(3R)-3-[4-(Acyloyl)amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one; 1-[(3R)-3-[4-(1-Oxo-2-propen-1-yl)amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one; N6-Acryloyl Ibrutinib
Long Term Storage Condition	Store under 2° to 8°C, Protect from light Under Normal condition
Handling instruction	Sample COA

Test	Results
Appearance	Off-White Solid
Water content by KF/TGA	Sample COA
% Potency = [100 - (Water content by KF)] X HPLC Purity)] / 100	Sample COA
Identification by HNMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Solubility	DMSO
Purity	NLT 98%
Analysis Date (Release Date)	Sample COA
Attachments	Sample COA
Other Information	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption