PRODUCT NAME: Abemaciclib Nitroso Impurity 4
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	NIO-749
Lot Number	Sample COA
Batch Quantity	Sample COA
CAS Number	NA
Mol. Formula	C28H33F2N7O
Molecular Wt	521.6 g/mol
Long Term Storage Condition	–20°C (long-term, under inert gas like N2/Ar to prevent oxidation)	Handling instruction	Sample COA
IUPAC	5-((4-Ethylpiperazin-1-yl)methyl)-2-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)methyl)pyridine 1-oxide
Chemical Name	Abemaciclib Nitroso Impurity 4
Synonyms	Abemaciclib Nitroso Impurity 4

Test	Results
Appearance	Light yellow to pale brown solid
Identification by 1H NMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Purity	NLT 98%
Wt. Loss by TGA	Sample COA
% Potency	Sample COA
Solubility
QC Release Date	Sample COA
Attachments	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption