PRODUCT NAME: Afatinib Impurity 22
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	AFI-019
Item/Batch Number	Sample COA
Quantity	Sample COA
CAS Number	NA
Mol. Formula	C28H29ClFN5O7
Molecular Wt	601.1 g/mol
IUPAC	N-(3-Chloro-4-fluorophenyl)-N-(6-((E)-4-(dimethylamino)but-2-enamido)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)-L-aspartic acid
Synonyms	N-(3-Chloro-4-fluorophenyl)-N-(6-((E)-4-(dimethylamino)but-2-enamido)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)-L-aspartic acid
Long Term Storage Condition	-20°C (desiccated)
Handling instruction	Sample COA

Test	Results
Appearance	Off-white to pale yellow lyophilized powder
Water content by KF/TGA	Sample COA
% Potency = [100 - (Water content by KF)] X HPLC Purity)] / 100	Sample COA
Identification by HNMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Solubility
Purity	NLT 98%
Analysis Date (Release Date)	Sample COA
Attachments	Sample COA
Other Information	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption