CERTIFICATE OF ANALYSIS

PRODUCT NAME: Cabozantinib (s) Malate
Date of Mfg: Sample COA RETEST DATE: Sample COA
Catalogue Number CAO-001
Lot Number Sample COA
Batch Quantity Sample COA
CAS Number 1140909-48-3
Alternate CAS Number 849217-68-1 (free base) ; 1786398-76-2 (HBr salt)
Mol. Formula C28H24FN3O5 : C4H6O5
Molecular Wt 501.5 : 134.1 g/mol
Long Term Storage Condition 2°C to 8°C Handling instruction Sample COA
IUPAC N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinate
Chemical Name Cabozantinib (s) Malate
Synonyms Cabozantinib S-malate; cabozantinib (S)-malate; Cabometyx
Test Results
Appearance White to Off-White
Identification by 1H NMR Sample COA
Identification By IR Sample COA
Mass (ESI) Sample COA
Purity NLT 98%
Wt. Loss by TGA Sample COA
% Potency Sample COA
Solubility DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly)
QC Release Date Sample COA
Attachments Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption
This is Sample COA