PRODUCT NAME: Nintedanib Esylate Impurity F
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	NNT-014
Item/Batch Number	Sample COA
Quantity	Sample COA
CAS Number	2410284-90-9
Mol. Formula	C56H52N8O8
Molecular Wt	965.1 g/mol
IUPAC	Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))(3Z,3'E)-bi
Synonyms	Nintedanib Esilate - Impurity F (EP/BP) (As per EP Monograph 37.2); Dimethyl 3,3'-(((((2,2'-(piperazine-1,4-diyl)bis(acetyl))bis(methylazanediyl))bis(4,1-phenylene))bis(azanediyl))bis(phenylmethanylylidene))(3Z,3'Z)-bis(2-oxoindoline-6-carboxylate); Methyl (3Z)-3-{[(4-{2-[4-({[4-({[(3Z)-6-(methoxycarbonyl)-2-oxo-2,3-dihydro-1H-indol-3-ylidene] (phenyl) methyl}amino)phenyl](methyl)carbamoyl}methyl)piperazin-1-yl] -N-methyl acetamido}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Long Term Storage Condition	2-8°C for long-term storage
Handling instruction	Sample COA

Test	Results
Appearance	Yellow powder
Water content by KF/TGA	Sample COA
% Potency = [100 - (Water content by KF)] X HPLC Purity)] / 100	Sample COA
Identification by HNMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Solubility
Purity	NLT 95%
Analysis Date (Release Date)	Sample COA
Attachments	Sample COA
Other Information	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption