PRODUCT NAME: Acalabrutinib Dimer Impurity 3
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	ATB-025
Lot Number	Sample COA
Batch Quantity	Sample COA
CAS Number	NA
Mol. Formula	C52H46N14O
Molecular Wt	931.0 g/mol
Long Term Storage Condition	Solution: Liquid N2 vapor phase (-150°C) for stocks	Handling instruction	Sample COA
IUPAC	4-(7-(4-((S)-2-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl)-4-oxobut-2-en-2-yl)-3-((S)-1-(but-2-ynoyl)pyrro
Chemical Name	Acalabrutinib Dimer Impurity 3
Synonyms	(S,S)-Ene-Butynyl PROTAC EGFR/VHL-002 (proprietary code); 4-[(7-{4-[(S)-2-(8-Amino-1-{4-[(pyridin-2-yl)carbamoyl]phenyl}imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl]-4-oxobut-2-en-2-yl}-3-{(S)-1-[(but-2-ynoyl)pyrrolidin-2-yl]-8-imino-7,8-dihydroimidazo[1,5-a]pyrazin-1-yl]-N-(pyridin-2-yl)benzamide

Test	Results
Appearance	Pale orange lyophilized powder (amorphous)
Identification by 1H NMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Purity	NLT 98%
Wt. Loss by TGA	Sample COA
% Potency	Sample COA
Solubility
QC Release Date	Sample COA
Attachments	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption