PRODUCT NAME: Acalabrutinib Impurity 22
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	ATB-012
Lot Number	Sample COA
Batch Quantity	Sample COA
CAS Number	1420478-87-0
Mol. Formula	C18H16BrClN4O2
Molecular Wt	435.7 g/mol
Long Term Storage Condition	2-8°C Refrigerator	Handling instruction	Sample COA
IUPAC	Benzyl (S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Chemical Name	Acalabrutinib Impurity 22
Synonyms	1-Pyrrolidinecarboxylic acid, 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)-, phenylmethyl ester, (2S); Phenylmethyl (2S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)-1-pyrrolidinecarboxylate; (S)-Benzyl 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Test	Results
Appearance	Pale yellow to light brown crystalline powder
Identification by 1H NMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Purity	NLT 98%
Wt. Loss by TGA	Sample COA
% Potency	Sample COA
Solubility
QC Release Date	Sample COA
Attachments	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption