PRODUCT NAME: Afatinib Impurity 42
Date of Mfg: Sample COA	RETEST DATE: Sample COA

Catalogue Number	AFI-044
Item/Batch Number	Sample COA
Quantity	Sample COA
CAS Number	2413212-27-6
Mol. Formula	C27H27ClFN5O7
Molecular Wt	588.0 g/mol
IUPAC	(S,E)-2-((3-chloro-4-fluorophenyl)(6-(4-(dimethylamino)but-2-enamido)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)amino)malonic acid
Synonyms	2-[(3-Chloro-4-fluorophenyl)[6-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinyl]amino]propanedioic acid; Propanedioic acid, 2-[(3-chloro-4-fluorophenyl)[6-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinyl]amino]
Long Term Storage Condition	-20°C or below, protected from light and moisture
Handling instruction	Sample COA

Test	Results
Appearance	white to off-white solid powder
Water content by KF/TGA	Sample COA
% Potency = [100 - (Water content by KF)] X HPLC Purity)] / 100	Sample COA
Identification by HNMR	Sample COA
Identification By IR	Sample COA
Mass (ESI)	Sample COA
Solubility
Purity	NLT 98%
Analysis Date (Release Date)	Sample COA
Attachments	Sample COA
Other Information	Sample COA
Note: This material can be used as a referance standard and is for research purpose ONLY and not for human consumption